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17. furosemide lasix 2S, 6R 2 methyl 6 1H pyrazol 3 yl 4 4 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl morpholine, I 138 3 2 3R, 5 S 3 1, 3 dimethyl 1H pyrazol 4 yl 5 methylpiperidin 1 yl pyrimidin 4 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 139 3 2 3 S, 5R 3 1, 3 dimethyl 1H pyrazol 4 yl 5 methylpiperidin 1 yl pyrimidin 4 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 140 3 2 3 S, 5 S 3 1, 3 dimethyl 1H pyrazol 4 yl 5 methylpiperidin 1 yl pyrimidin 4 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 141 3 2 3R, 5R 3 1, 3 dimethyl 1H pyrazol 4 yl 5 methylpiperidin 1 yl pyrimidin 4 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 142 3 2 3R, 5R 3 1 2 methoxyethyl 1H pyrazol 4 yl 5 methylpiperidin 1 yl pyrimidin 4 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 143 3 2 3R, 5S 3 1 2 methoxyethyl 1H pyrazol 4 yl 5 methylpiperidin 1 yl pyrimidin 4 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 144 3 2 3 S, 5R 3 1 2 methoxyethyl 1H pyrazol 4 yl 5 methylpiperidin 1 yl 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6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl morpholine 2 carboxamide, I 163 R 1 2 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3 carboxamide, I 164 2 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidin 3 yl acetic acid, I 165 2 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidin 3 yl acetamide, I 166 3 S, 5R 1 4 6 chloroimidazo 1, 2 a pyridin 3 yl 5 methylpyrimidin 2 yl 5 methylpiperidin 3 yl imino dimethyl О»6 sulfanone, I 167 3 S, 5R 1 4 6 chloroimidazo 1, 2 a pyridin 3 yl 6 methylpyrimidin 2 yl 5 methylpiperidin 3 yl imino dimethyl О»6 sulfanone, I 168 dimethyl 3 S, 5R 5 methyl 1 4 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl piperidin 3 yl imino О»6 sulfanone, I 169 3 2 2S, 5 S 2, 5 dimethyl 3 1H pyrazol 4 yl piperazin 1 yl pyrimidin 4 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 170 3 2 2R, 5R 2, 5 dimethyl 3 1H pyrazol 4 yl piperazin 1 yl pyrimidin 4 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 171 3 2 2S, 5S 2, 5 dimethyl 3 5 methyl 1H pyrazol 4 yl piperazin 1 yl pyrimidin 4 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 172 3 2 2R, 5R 2, 5 dimethyl 3 5 methyl 1H pyrazol 4 yl piperazin 1 yl pyrimidin 4 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 173 S 1 4 6 chloroimidazo 1, 2 a pyridin 3 yl 5 methylpyrimidin 2 yl piperidine 3 carboxamide, I 174 2S, 6S 4 2 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl 2 5 fluoro 1H pyrazol 4 yl 6 methylmorpholine, I 175 2R, 6S 4 2 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl 2 5 fluoro 1H pyrazol 4 yl 6 methylmorpholine, I 176 2S, 6R 4 2 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl 6 methylmorpholine 2 carboxamide, I 177 2R, 6R 4 2 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl 6 methylmorpholine 2 carboxamide, I 178 2S, 6R 4 4 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl 2 methyl 6 5 methyl 1H pyrazol 4 yl morpholine, I 179 2R, 6S 4 4 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl 2 methyl 6 5 methyl 1H pyrazol 4 yl morpholine, I 180 2S, 6S 4 4 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl 2 methyl 6 5 methyl 1H pyrazol 4 yl morpholine, I 181 2R, 6R 4 4 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl 2 methyl 6 5 methyl 1H pyrazol 4 yl morpholine, I 182 S 1 4 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl piperidine 3 carboxamide, I 183 6 chloro 3 5 methyl 2 3R, 5 S 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 184 6 chloro 3 5 methyl 2 3R, 5R 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 185 6 chloro 3 5 methyl 2 3 S, 5 S 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 186 N 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidin 3 yl acetamide, I 187 4 methyl 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 4 carboxamide, I 188 2S, 6S 2 methyl 6 2H tetrazol 5 yl 4 4 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl morpholine, I 189 2R, 6R 2 methyl 6 2H tetrazol 5 yl 4 4 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl morpholine, I 190 3 S, 5R 1 2 6 chloro 7 fluoroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl 5 methylpiperidin 3 yl imino dimethyl О»6 sulfanone, I 191 3 methyl 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3 carboxamide, I 192 3 4 2 5 difluoromethyl 1H pyrazol 4 yl morpholino pyrimidin 2 yl imidazo 1, 2 a pyridine 6 carbonitrile, I 193 6 chloro 3 2 3R, 5 S 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 195 6 chloro 3 2 3R, 5R 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 196 6 chloro 3 5 methyl 2 3 S, 5R 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 197 6 chloro 3 2 3 S, 5R 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 198 6 chloro 3 2 3 S, 5 S 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 199 6 methyl 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3 carboxamide, I 200 6 methyl 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3 carboxylic acid, I 201 2S, 6R 4 4 6 chloroimidazo 1, 2 a pyridin 3 yl 5 methylpyrimidin 2 yl 2 methyl 6 5 methyl 1H pyrazol 4 yl morpholine, I 203 2R, 6S 4 4 6 chloroimidazo 1, 2 a pyridin 3 yl 5 methylpyrimidin 2 yl 2 methyl 6 5 methyl 1H pyrazol 4 yl morpholine, I 204 5, 5 Difluoro 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3 carboxylic acid, I 205 5 fluoro 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3 carboxylic acid, I 206 tert butyl 2 carbamoyl 4 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperazine 1 carboxylate, I 207 6 chloro 3 6 methyl 2 3 S, 5 S 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 208 6 chloro 3 6 methyl 2 3R, 5R 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 209 6 chloro 3 6 methyl 2 3 S, 5R 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 210 6 chloro 3 6 methyl 2 3R, 5 S 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 211 tert butyl 3 hydroxy 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3 carboxylate, I 212 3 hydroxy 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3 carboxamide, I 213 3 hydroxy 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3 carboxylic acid, I 214 4 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperazine 2 carboxamide, I 217 2R, 6R 4 4 6 chloroimidazo 1, 2 a pyridin 3 yl 6 methylpyrimidin 2 yl 2 methyl 6 5 methyl 1H pyrazol 4 yl morpholine, I 218 S 1 5 fluoro 4 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl piperidine 3 carboxamide, I 219 2S, 6S 4 4 6 chloroimidazo 1, 2 a pyridin 3 yl 6 methylpyrimidin 2 yl 2 methyl 6 5 methyl 1H pyrazol 4 yl morpholine, I 220 2S, 6R 4 4 6 chloroimidazo 1, 2 a pyridin 3 yl 6 methylpyrimidin 2 yl 2 methyl 6 5 methyl 1H pyrazol 4 yl morpholine, I 221 2R, 6S 4 4 6 chloroimidazo 1, 2 a pyridin 3 yl 6 methylpyrimidin 2 yl 2 methyl 6 5 methyl 1H pyrazol 4 yl morpholine, I 222 R 1 5 fluoro 4 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl piperidine 3 carboxamide, I 223 3 4 3, 3 difluoropiperidin 1 yl pyrimidin 2 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 224 2 difluoromethyl 4 2 6 trifluoromethyl imidazo 12 a pyridin 3 yl pyrimidin 4 yl morpholine, I 225 3 4 3 fluoro 3 methylpiperidin 1 yl pyrimidin 2 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 226 S 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3 carbonitrile, I 227 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl azetidine 3 carboxamide, I 228 5 fluoro 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3 carboxamide, I 229 2 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl azetidin 3 yl acetamide, I 230 3 4 3, 5 dimethylpiperazin 1 yl pyrimidin 2 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 231 S 4 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl morpholine 2 carbonitrile, I 232 S 6 trifluoromethyl 3 4 3 trifluoromethyl piperidin 1 yl pyrimidin 2 yl imidazo 1, 2 a pyridine, I 233 3 4 3, 5 dimethyl 4 oxetan 3 yl piperazin 1 yl pyrimidin 2 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 234 6 cyclopropyl 3 2 3 S, 5R 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 235 6 cyclopropyl 3 2 3R, 5S 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 236 tert butyl 3 S, 5 S 5 hydroxy 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidin 3 yl carbamate, I 237 3R, 5 S 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3, 5 diol, I 238 3 S, 5S 5 amino 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidin 3 ol, I 239 3 4 3R, 4R 3 fluoro 4 methylpiperidin 1 yl pyrimidin 2 yl 6 trifluoromethyl imidazo 1, 2 a pyridine, I 240 3 hydroxymethyl 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidin 4 ol, I 241 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3 sulfonamide, I 242 tert butyl 3R, 4R 1 2 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl 4 hydroxypiperidin 3 yl carbamate, I 243 3 S, 5R 1 4 6, 7 dichloroimidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl 5 methylpiperidin 3 yl imino dimethyl О»6 sulfanone, I 244 4 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl 1 3, 3, 3 trifluoropropyl piperazine 2 carboxamide, I 245 2S, 6S 4 4 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl 2 methyl 6 1H pyrazol 4 yl morpholine, I 246 6 Chloro 3 imidazo 1, 2 a pyridine, I 247 6 Chloro 3 imidazo 1, 2 a pyridine, I 248 6 Cyclopropyl 3 imidazo 1, 2 a pyridine, I 249 6 Cyclopropyl 3 imidazo 1, 2 a pyridine, I 250 2R, 6R 4 4 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl 2 methyl 6 1H pyrazol 4 yl morpholine, I 251 tert butyl 3R, 5R 1 2 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl 5 methylpiperidin 3 yl carbamate, I 252 2 hydroxy N 3 S, 5 S 5 hydroxy 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidin 3 yl acetamide, I 253 2 hydroxy N 3 S, 5S 5 hydroxy 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidin 3 yl propanamide, I 254 3R, 4R 3 amino 1 2 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidin 4 ol, I 255 3R, 5R 1 2 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl 5 methylpiperidin 3 amine, I 256 N 3 S, 5S 5 hydroxy 1 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidin 3 yl 1H pyrazole 4 carboxamide, I 257 1 2 methoxyethyl 4 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperazine 2 carboxamide, I 258 6 3, 3 difluoroazetidin 1 yl 3 2 3 S, 5R 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 259 R 1 3 fluoro 6 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyridin 2 yl piperidine 3 carboxamide, I 260 6 3, 3 difluoroazetidin 1 yl 3 2 3R, 5S 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 261 3 4 3 S, 5R 3 dimethyl oxo О»6 sulfaneylidene amino 5 methylpiperidin 1 yl pyrimidin 2 yl imidazo 1, 2 a pyridine 6 carbonitrile, I 262 1 oxetan 3 yl 4 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperazine 2 carboxamide, I 263 2S, 6S 6 methyl 4 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl morpholine 2 carboxamide, I 264 2S, 6R 6 methyl 4 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl morpholine 2 carboxamide, I 265 6 chloro 3 4 3 methyl 5 1H pyrazol 4 yl piperazin 1 yl pyrimidin 2 yl imidazo 1, 2 a pyridine, I 266 6 chloro 3 4 3 methyl 5 5 methyl 1H pyrazol 4 yl piperazin 1 yl pyrimidin 2 yl imidazo 1, 2 a pyridine, I 267 6 chloro 3 4 3 methyl 5 5 methyl 1H pyrazol 4 yl 4 methylsulfonyl piperazin 1 yl pyrimidin 2 yl imidazo 1, 2 a pyridine, I 268 3 S, 5R 1 2 6, 7 dichloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl 5 methylpiperidin 3 yl imino dimethyl О»6 sulfanone, I 269 2S, 6R 4 4 6 chloro 7 fluoroimidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl 2 methyl 6 1H pyrazol 4 yl morpholine, I 270 6 azetidin 1 yl 3 2 3 S, 5R 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 271 6 azetidin 1 yl 3 2 3R, 5R 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 272 2R, 6S 4 4 6 chloro 7 fluoroimidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl 2 methyl 6 1H pyrazol 4 yl morpholine, I 273 2R, 6R 4 4 6 chloro 7 fluoroimidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl 2 methyl 6 1H pyrazol 4 yl morpholine, I 274 2S, 6S 4 4 6 chloro 7 fluoroimidazo 1, 2 a pyridin 3 yl pyrimidin 2 yl 2 methyl 6 1H pyrazol 4 yl morpholine, I 275 1 4 2 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl 2 methyl 6 3 methyl 1H pyrazol 4 yl piperazin 1 yl ethan 1 one, I 276 1 4 2 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl 2 methyl 6 1H pyrazol 4 yl piperazin 1 yl ethan 1 one, I 277 S 1 5 fluoro 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3 carboxamide, I 278 6 chloro 3 6 methoxy 2 3R, 5R 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 279 6 chloro 3 6 methoxy 2 3R, 5S 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 280 6 chloro 3 6 methoxy 2 3 S, 5 S 3 methyl 5 1H pyrazol 4 yl piperidin 1 yl pyrimidin 4 yl imidazo 1, 2 a pyridine, I 281 S 1 5 fluoro 2 6 trifluoromethyl imidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidine 3 carboxamide, I 282 N 1 2 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidin 3 yl methyl N methylmethanesulfonamide, I 283 2 1 2 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl piperidin 3 yl 2 methylpropanoic acid, I 284 tert butyl 6 2 6 chloroimidazo 1, 2 a pyridin 3 yl pyrimidin 4 yl 2, 6 diazaspiro 3

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